The Rarest Cannabis Strains in 2023

by | May 22, 2023 | Cannabis E-commerce, Seed & Strain Creation

One of the most incredible things about cannabis is the massive variety of unique strains — also known as cultivars — that growers have bred over the years. 


Growers, distributors, and seedbanks should stock a good variety of both classic, crowd-pleasing strains and rare cultivars that few others offer. Symple Seeds carries both popular cultivars and rare strains that will impress your customers and clients. Read on for a list of some of our favorites. 

The Most Popular Cannabis Cultivars


These cultivars are classics. Trends in cannabis come and go, but these well-known strains are always sure sellers on dispensary shelves. 

Popular Sativa Strains Cannabis Consumers Love


True sativa cultivars are harder to find than many people assume. Strains in this category tend to be uplifting and energizing, but they can be overwhelming for the unprepared. 

Durban Poison

One of the most popular sativa cultivars, Durban Poison is loved for its energetic and uplifting effects. Many say this spicy, herbal strain helps them focus, too. 

Sour Diesel

This sativa strain has an intense, skunky flavor profile with pungent diesel notes. Fans of the cultivar say it helps them feel energized, social, and ready to take on projects from new angles. 

Strawberry Cough

A sativa cultivar that’s ideal for those who like fruity strains, Strawberry Cough lives up to its name with sweet berry flavors. It’s said to be energizing and mood-boosting. 

Jack Herer

Named after the famous cannabis activist, Jack Herer is an energizing, uplifting sativa strain known for boosting creativity. With notes of woody pine and mellow herbs, it’s no surprise that this is an award-winning cultivar.

Popular Indica Strains for Relaxation

Indica strains tend to be relaxing and low-energy. Some love these strains to help them relax at the end of the day, but some find them too sedating.

Granddaddy Purp

This strain has many names but is instantly recognizable thanks to its vibrant purple buds and rich, grapey flavor. Fans love it for its relaxing, sleep-inducing effects. 

Ice Cream Cake

Another popular indica strain, Ice Cream Cake is also known for bringing on a relaxed, sleepy state of mind. It tastes like sweet, creamy vanilla.

Bubba Kush

This chilled-out indica cultivar is known for being appetite- and sleep-inducing. Deep, rich, and earthy with notes of coffee and chocolate, this cultivar is one for the gourmands. 

Grape Ape

Grape Ape is another indica cultivar that tastes and smells like grapes, but this one is sweeter than Grandaddy Purp. Fans of this strain say it makes them feel relaxed, tranquil, and hungry.   

Popular Hybrid Strains for Every Cannasseur

Many popular, widespread strains are technically hybrids. These cultivars tend to provide a good balance of uplifting and relaxing effects, making them more appealing to a wider audience. 

OG Kush

This strain is a true hybrid with a complex, slightly skunky smell and taste. Fans of OG Kush say it makes them feel hungry, relaxed, and euphoric. 

Pineapple Express

This iconic strain is a sativa-leaning hybrid and was made popular by the Seth Rogen movie of the same name. Fans say it tastes like tropical fruit and helps them feel energetic and upbeat. 

Blue Dream

Blue Dream is a classic sativa-leaning hybrid. It’s one of the most well-known cannabis strains, with flavor notes of sweet berries and uplifting, creativity-boosting effects. 

Wedding Cake

This Indica-leaning hybrid strain was California’s best-selling strain in 2022. It tastes like sweet vanilla; fans say it’s relaxing and appetite-stimulating. 

The Rarest Cannabis Strains

If your customers have already tried the most popular strains and want something new, give them what they want with some rare, exciting cultivars. 

Many of these rare strains are true indicas or sativas; as hybrids have gotten more popular and cannabis breeders have become more prolific, it has become harder to find these “pure” strains in dispensaries. Many are also more difficult to grow or have a longer flowering time, so these rare strains are great options for growers looking for a challenge. 

Get Energized With Rare Sativa Strains

These sativa strains are all very potent and are known to produce intense experiences the average cannabis consumer might not expect.

Malawi Gold

This potent sativa cultivar is a landrace, which means it originated in a specific place and still carries unique traits that stem from that location. In this case, Malawi Gold is native to Malawi, a sub-tropical country in Southeastern Africa. These old, un-hybridized strains usually have very unique properties, and Malawi Gold is no exception. It’s exceptionally energizing and uplifting, and it has a unique flavor profile with fresh tropical notes and tarry flavors. 

Amnesia Haze

This cultivar is popular in the coffee shops of Amsterdam and has won the Cannabis Cup twice, but it’s still a hard-to-find and highly sought-after cultivar. Fans lucky enough to have tried it say this citrus-flavored cultivar makes them feel energized, talkative, and giggly. 

Panama Red

Panama Red was incredibly popular in the late 1960s but has become more challenging to find in modernity. This strain has a longer flowering time than many other modern cultivars, but its mood-bosting effects and herbal, tropical flavor make it well worth the wait.

Take a Relaxing Smoke Break with Rare Indica Strains

These rare indica cultivars are intensely relaxing and sedating. 

Bubba OG

This indica cultivar is distantly related to OG Kush, but this one is much more difficult to find. Fans say it makes them feel sleepy, relaxed, and hungry. Bubba OG has a balanced flavor that’s equal parts sweet and pungent. 

Sweet Tooth

Sweet Tooth is another winner of the Cannabis Cup that’s become very hard to find in recent years. Even though it’s a true indica, this rare strain has fairly balanced effects; fans who have gotten their hands on Sweet Tooth seeds say that the flower is sweet, floral, and fruity, making them feel euphoric and relaxed at the same time. 

Hindu Kush

Hindu Kush is also a landrace. This potent indica cultivar is native to the Hindu Kush mountains between Pakistan and Afghanistan and is known for being incredibly relaxing and sleep-inducing. Its spicy, herbal flavor profile perfectly complements its mellow feel. 

Rare Hybrid Strains Every Cannabis Consumer Should Try

Most rare cannabis cultivars are indicas or sativas, but some hard-to-find and highly sought-after hybrids are still out there. 

Mendocino Purps

This award-winning hybrid cultivar is immediately recognizable thanks to its bright purple color. Fans say this rare hybrid makes them feel relaxed and happy. It’s known to stimulate appetite and tastes like sweet grapes and fresh, floral berries. 

Puna Budder

Puna Budder has a unique flavor profile, with skunky and buttery flavors against an herbal backdrop. Fans who can get their hands on this cultivar say it’s uplifting and giggle-inducing, making it perfect for socializing.

NYC Diesel

This slightly sativa-leaning cultivar hails appropriately from the city that never sleeps. It tastes like diesel and citrus, which makes for an energizing flavor combination. Fans of this rare hybrid strain say it’s energizing and makes them feel extra talkative. 

Create the Hottest New Cannabis Strains

If none of these strains are exactly what you’re looking for, you might want to consider breeding a new cultivar. Luckily, Symple Seeds can help with that process.

Symple Seeds has a massive library of cannabis seeds and a team of top-tier geneticists on staff. We can source rare seeds for your company, create seeds from your signature strains, and help you develop your own unique cultivar. With many other seed and strain creation options at Symple Seeds, we can help your cannabis company reach new heights. 

Where to Buy Cannabis Seeds Online

Symple Seeds is the best online source for cannabis seeds. We have a massive library of available seeds and custom seed creation services. With wholesale, drop-shipping, and e-commerce options, Symple Seeds can help your cannabis business grow. Contact us today to start designing your own strain.

Contact us today for tailor-made cannabis seed solutions.

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